I would switch out Ober for Ryan for the Hou series. Ryan has pitched 10 innings against Hou given up 9 runs (4 home & 5 away) and 3 HR. Neither Maeda or Ober pitched against Hou this year. The following is the road IP, ERA, HR, WHIP and ERA for last 7 games for each pitcher:
Ryan 79.1, 5.22, 20, 1.26 & 4.79
Maeda 59.1, 3.03, 8, 1.04 & 4.41
Ober 68.0, 3.57, 9, 1.06 & 3.53
I can make a strong argument for either Maeda or Ober to start game 1. If the Twins are as analytical as they claim they wouldn't let Ryan face Hou.