Usually, when a pitcher is nearing 100 pitches and he only uses around 15 or less pitches to finish his last inning, the Twins leave him in the game for another inning. If he breezes through that inning, they will leave him in for another. I watch or listen to almost all Twins games and I rarely disagree with timing of when they bring in a reliever. That is one of the reasons I support Gardy/Andy is that the pitchers have earned the right to pitch another inning. I remember, about 20 years ago, or so, there was a study out that said exactly that pitchers tend to pitch the next game more poorly after pitching around 115+ innings in the previous game. Somewhere between 100 & 110 pitches was ideal. I have looked for this study online, but I haven't found it.