I've never cared for interleague play when the AL team couldn't use the DH in NL parks. Now, with uniform rules (or if there's differences in the leagues, it's so minor I can't think of them as I sit here), it's time to consider realignment. I did this about as fast as I could type it, and don't pretend it couldn't be improved:
Northeast:
Toronto
Yankees
Mets
Phillies
Boston
Southeast
Washington
Baltimore
Atlanta
Tampa
Miami
North
Twins
Guardians
Brewers
Tigers
Pirates
Midwest
Cardinals
Royals
White Sox
Cubs
Reds
Southwest:
Astros
Rangers
Colorado
Angels
Dodgers
West:
Seattle
SF
Oakland
San Diego
D'Backs
The logic, or what little there was, intended to keep the NY, CHI and LA teams in the same division, so as to make it easier for fans of one team to travel to the other ballpark--same with WASH and BAL, SF and OAK. More ticket sales, better for the bottom line. Admittedly, AZ and COL presented a problem, as did dividing the two teams from Pennsylvania.
But this is a framework of what could be. Now, if MLB expands to 32 teams, you'd have 8 divisions with 4 teams each, and many of the same problems in lining it all up.
JcS