Cyanide and Happiness are good, I can't say I know Bloom County all that well. I'd rank Far Side, Peanuts, and Calvin and Hobbes as top three. You're right when you say C + H lining up with our childhood was a part of it, but I've enjoyed that strip at every stage of my life and now re-enjoying it as a father of a son. (Who, by the way, is named Calvin) I don't think any other comic manages to be so profound, so whimsical, so philosophical, so heartfelt, so utterly in tune to the essence and spirit of childhood, and so creatively able to capture the human condition. It's just so perfect. Far Side is witty and philosophical and profound, but not whimsical or heartfelt. Peanuts has many of the traits of Calvin and Hobbes but, for me, feels overtaken in every one of them.