MLB did that already, in 1969. But really, I know what you mean and I suppose it is a possibility but there are big roadblocks. Cuba, Venezuela and the Dominican Republic would probably have enough interest in a major league franchise but not enough money or stability. Japan would probably have enough interest and money, but road trips to the west coast are bad enough. A 162-game MLB schedule involving a Japanese team would, I think, be either unfair, unworkable or both. Europe would not be any better. My guess is that Mexico City is about the only place outside the US and Canada that would have any chance.