I highly doubt the return from Mike Pelfrey would improve the team in the near term or the short term. Plus, think about it. Who trades for rentals? Other contenders. Well if the Twins are in contention at the deadline, they're not going to want to improve another AL contender so right there the market is narrowed to NL teams, further whittling any return to at best Escobar lite (lite).
But, I would love to see this team trade from their prospect pool. They have yet another top 10 pick coming, they can afford to. A prospect package for a promising young player in his 20s who is maybe pre-arb or early in arbitration would be ideal IMO.