I realize this is a touchy subject, but you asked, so: Standardize whether or not the DH is used. My personal preference is to get rid of it, but I understand the practical difficulty in that, so I'll accept everybody using it - just everybody use the same rules. I know some like the diversity between the leagues and the effect it has on interleague play and world series, but I'm not sold on that.
I'm also ready, especially if my above proposal is rejected, to scrap interleague play - keep it in the leagues, play a balanced or semi-balanced schedule, and only have the leagues meet in the Series.
OK, OK, I'll admit, I'm a traditionalist. I'm not big on the wild card thing either.