I was a very serious mountain biker for about a decade. I don't ride much anymore (I'm 43), and still have my 26" bike for rides with my kids. I have a Santa Cruz Blur LT, which is the best bike I've ever owned. At the time it was worth more than the 14-year old 4Runner I drove. That definitely sounds like the right frame size if you're 6'1". I'm just a shade shorter than you - about 6'1/2" - and also have a 21" frame. I think the consensus is that 29" wheels are smoother over rocky terrain, and the perceived increase in rolling resistance isn't even an issue. Almost all my serious biker friends who still ride have gone to 29" wheels, and wouldn't go back. If I was in the market for a bike now, it would absolutely be a 29". Of course, it depends on your terrain. We have a ton of rocks here in the Black Hills of South Dakota, so the larger wheel is a real plus as it can roll over terrain where a smaller 26" wheel will have trouble. If this is your first bike, I would recommend going to a dedicated bike shop (a lot of forums refer to this as an LBS - local bike shop). You'll pay a little more, but you'll get a bike that's the right size for you and will have access to tuneups, maintenance, and quality safety gear (a good helmet is the most important thing, of course). If you're not planning on riding really aggressive terrain (lots of rocks, big drop-offs, etc.), you can save money by going with what's called a hard-tail. This means there's only suspension in the front - the fork. The rear tire wouldn't have a shock. You can get a lot more bike for the money if you can fore-go that rear shock. Of course, if you're planning on riding more aggressive terrain, you'll likely want that shock. The terrain where I ride is extremely rocky, so pretty much everyone rides a full-suspension bike. But for a first bike, especially, I would take a serious look at a hard-tail. If you fall in love with the hobby, you can always upgrade to a FS (full suspension) bike later. Ok - enough already. Biking was my consuming passion for an entire decade, and I still get pumped just talking about it. My time is now spent with my wife and kids, and I don't ride much anymore - but it's an incredible hobby and I only wish I'd started riding at 20 instead of 30. By the way, biking probably saved my life. At 32, I had a severe blockage of my LAD coronary artery - they call that the "widowmaker". I weighed about 180 pounds, was in fantastic shape, ate right, didn't smoke, didn't drink, and rode my bike hard several days a week. And there I was, in the emergency room at 32, hearing the doctor tell me he was amazed I was alive. He said I had developed "collateral arteries" from all the mountain biking, and those collateral arteries are likely what saved my life. Without them, I'd probably have died of a massive heart attack. So, good luck with the bike purchase. I hope you enjoy the hobby as much as I have.