I listen to several really smart podcasts and I haven't heard anyone really explore this topic in-depth.
Unlike previous years, the AL and NL are going to square off in 33% of their games. That's a lot.
Except the AL has a monstrous advantage this year, or at least part of the AL has this advantage... a dedicated hitter who rakes well above standard league production with the bat.
Over 20 games, how are NL teams going to compete against the teams (like the Twins) that have a 1.000+ OPS hitter already established in the DH position?
NL teams didn't have the time or ability to really compensate for this problem (inexplicably, Puig remains unsigned...) and they're going to be pitting .700-ish OPS players against top AL teams that will have .900+ OPS hitters in the same position.
I have to imagine that, when this year ends, the interleague numbers are going to be heavily slanted to the AL.