My (ridiculous) take:
The Yankees have a questionable rotation and a strong bullpen, while the Astros are just the opposite. If I want the Twins best chance of advancing one round, I'd take the Yankees first. BUT, if I want the Twins best chance of advancing to the WS, I want the Yankees 2nd. My thoughts being that the Yankees are going to run away with their division and can rest their pen late in the regular season, so I would like Oak/TB/Cle to force them to put some innings on those arms, possibly keeping some of them unavailable or limited early in the next series..
So far this year, the Twins OPS in the first 5 innings is about 100 points higher than it is in the rest of the game. I like the offense's chances against Houston's top end starters more than I do New York's top end relievers, so if I got to pick one I'd rather not get extra rest, it'd be the relievers.