Competitively, each team plays 81 at home and 81 on the road.
There is no competitive advantage to playing more home early or late.
But in the playoffs, teams with home field advantage get home games first for a reason.
If you are talking about spending the entire first month of a six month season completely at home or on the road, like some in this thread have suggested, I think it could have a competitive impact on the season. As an example, a team with more home games early can "bank" more wins and put themselves in a better position at the trade deadline.
But yeah, there are many reasons why this will never happen, so I won't quibble with how one wants to rank them.